BDBM375198 6-{[(6-chloro-2-oxo-1,2-::US10253015, Compound I-58

SMILES Cc1nc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N

InChI Key InChIKey=BPIFALCAPCGTGS-UHFFFAOYSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 375198   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Forma Tm2

US Patent
LigandPNGBDBM375198(6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...)
Affinity DataIC50:  55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Forma Tm2

US Patent
LigandPNGBDBM375198(6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...)
Affinity DataIC50: >1.00E+3nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB